Nitazoxanide – A New Option in Biliary Ascariasis
DOI:
https://doi.org/10.18034/ra.v7i1.236Keywords:
helminth infections, biliary ascariasis, nitazoxanideAbstract
This prospective study was conducted in the in-patient department of medicine, Chittagong Medical College Hospital (CMCH), Chittagong, Bangladesh from February 2016 to September 2016. The study included 70 patients admitted to emergency department of medicine. Clinical assessment was performed in all the cases. Detailed history was taken as per site, severity and nature of pain. Nitazoxanite is a newly recommended antihelminthic agent elicits its activity by interfering with pyruvate: ferredoxin oxidoreductase (PFOR) enzyme dependent electron transfer reaction, which is essential for anaerobic energy metabolism. It is given by the oral route with good bioavailability and is well tolerated, with primarily mild gastrointestinal side effects. Nitazoxanide (500mg) tablet was given twelve hourly for 3 days. Relieve of pain after taking antihelminthic was observed and serial ultrasonogram was performed to determine the worm present or absent in biliary tree. In this study majority of the patients presenting biliary ascariasis were females (74.3%) and the most common age group affected was within 18 to 35 years of age. Among the total respondents, 88.57% were cured, while only 11.43% were not cured off their diseases.
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