Age-Structured Effect of Evolution on Hepatitis B Vaccination in Bangladesh


  • Md. Abu Salek Bhawal Bodre Alam Government College
  • Md. Shahidul Islam University of Dhaka



HBV infection, Force of infection, Immunization, Stability, Hepatocellular, Disease dynamics, Disease-endemic equilibrium, Residual infections


The goal of this examine is to model the age-time established prevalence of hepatitis B whilst  estimating the impact of vaccination. While stochastic models/time series have been used before to version hepatitis B cases in the absence of know-how on the wide variety of susceptible, this paper proposes to apply a way that fits into the generalized additive version framework. Generalized additive models with penalized regression splines are used to make the most the    underlying continuity of each age and time in a bendy nonparametric way. Primarily based on a unique case notification dataset, it's far proven that the implemented immunization programme in Bangladesh ended in a huge lower in incidence for babies in their first year of existence with 82% (79%-84%). Moreover, its miles proved that conditional on an assumed baseline susceptibility percent; a clean force of infection profile can be received from which two local maxima had been determined at ages 9 and 24.



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Author Biographies

Md. Abu Salek, Bhawal Bodre Alam Government College

Departmental of Mathematics, Bhawal Bodre Alam Government College, Gazipur, Bangladesh

Md. Shahidul Islam, University of Dhaka

Department of Mathematics, University of Dhaka, Dhaka 1000, Bangladesh



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How to Cite

Salek, M. A. ., & Islam, M. S. . (2020). Age-Structured Effect of Evolution on Hepatitis B Vaccination in Bangladesh. ABC Research Alert, 8(2), 58–68.



Research Paper